Into the 70sof the 20th century, with the deepening of the medical basic theory research,the mechanism of ozone is becoming clear. Therefore, ozone therapy as anancient and innovative method is recognized by more and more medical workers around the world. In Europe, almost every country has one or moreozone therapy association. In 1972, Wolff and Hansler founded the first ozone society inGermany. Italy established its own society in 1984. In 1999, Italy launched and organized the International Association for the medical ozone (IMOS), which aims to promote the basic and clinical research of ozone and establish aperfect clinical treatment system, which is not driven by commercial interests.At present in Europe, the treatment of ozone is mainly used in trauma and refractory ulcer (such as diabetic foot treatment, cancer adjuvant therapy,lumbar intervertebral disc herniation and bone and joint diseases, anti freeradical anti aging, stroke and viral hepatitis and other diseases treatment,the clinical curative effect has been fully affirmed.
Professor Bocci made great contributions to basic research of ozone. Bocci Velio, a professor at Siena University in Italy, has been engaged in ozone therapy formany years, and noted that the treatment is controversial in clinical practice.Before 1984, it was reported that intravenous O3 injection of pulmonary infarction could lead to death. After 1984, this treatment is listed as illegal in Italy. Bocci review its original data and found that O3 intervertebral discinjection can make in the nucleus pulposus proteogly can degeneration so that the compression of the nerve root of intervertebral disc tissue atrophy,resulting in a "with O2 or O3 in a double-blind, randomized, and traditional methods of treatment in clinical studies and long-term follow-up is necessary conclusion , to lay the clinical ozone intervertebral disc treatment. In 2000, Bocci published "Therapy Oxygen-Ozone", a book that describes the ozone's physical and chemical properties and clinical applications, which is by far the world's most authoritative ozone therapy professional book.